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Integrating a Missing Element into Medical Education. National Academies Press US ; This appendix contains 55 case studies from peer reviewed literature, including journal articles and educational material developed by the Agency for Toxic Substances and Disease Registry ATSDR. They were selected for their clinical interest with respect to environmental factors and health, relevance to particular courses and clerkships in medical school, and illustrative potential for teaching medical school students about the impact of the environment on health.
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Lipid peroxidation generates unsaturated aldehydes that form conjugates with histidyl dipeptides. Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation.
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F 2 -isoprostanes F 2 -iPs , established markers of oxidative stress, exist as four sets of regioisomers. Isoprostanes iPs are products of the free radical-initiated autoxidation of arachidonic acid 1. F 2 -iPs are established markers for oxidative stress 2 — 4 and have been linked to cardiovascular diseases and risk factors 5. In addition, some F 2 -iPs exert potent biological activity by acting as ligands for either plasma membrane-bound prostaglandin PG receptors or nuclear receptors 6 — 8. F 2 -iPs are generated in situ esterified to phospholipids 9.
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